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Glia helps clear heat in the brain’s glymphatic system and enhance its Qi. It helps reduce the inflammation of the glymphatic system and enhances the brain’s waste drainage function. Brown, LC Balancer, and Xcel are also required for toxin processing and secretion.
Gliagen nurtures the Qi and Yin and clears the Wind from the brain’s glymphatic system. It helps repair the damage and reverse the degeneration of the glial cells to increase its drainage capacity and efficiency. It also helps relieve the constriction and vasospasm of the perivascular network to reduce the blood pressure and facilitate the transport of the waste drainage from the perivascular network to the body’s main lymphatic network.
The glymphatic system serves as a waste clearance pathway for vertebrate central nerve system (CNS). The glial-dependent glymphatic system is the replacement of lymphatic vessels in the CNS that is dedicated to draining away soluble waste proteins and metabolic products from the interstitial fluid (ISF). The name "glymphatic system" was coined by the Danish neuroscientist Maiken Nedergaard in 2014 in recognition of the dependence of the brain’s lymphatic system upon glial cells. Glymphatic system consists of glial cells including the microglia cells and astrocytes and the perivascular network. The collected wastes by the glial cells from the ISF are transported through the perivascular network which is connected to the body’s main lymphatic system on the dura, which a thick membrane of connective tissue that covers the brain.
The glymphatic system runs parallel to the arteries and harnesses the pulsing of blood in circulation to help keep things moving. As the blood vessels expand rhythmically, they drive the exchange of compounds between the interstitial fluid (ISF) and the cerebrospinal fluid (CSF). CSF fills the larger spaces within and around the CNS and serves as a reservoir. ISF surrounds the parenchymal cells of the brain and spinal cord which contains waste molecules.
As it was illustrated in the diagram at the right, the flow of the liquid is from right to left.
Mental stress or physical stress such as a summer heatwave, high temperatures, or being exposed to the sun for long periods could result in an increased level of free radicals or oxidative stress in the brain which can cause glial cell inflammation and slow down the drainage of the brains waste products. Patients may experience symptoms of dizziness, fatigue, headache, as well as decreased appetite. Chronic stress can cause irreversible damage to the glymphatic system. Severe life stress can cause psychological trauma which can also damage the glial cells severely. Patients may experience chronic headaches, nausea, and high blood pressure.
Waste removal from the central nervous system is essential for maintaining brain homeostasis across the lifespan. Studies have documented that soluble amyloid-beta (Aβ) protein and tau oligomers and other metabolic waste products were transported from the interstitial fluid (ISF) space and out of the brain via the glymphatic system.
Studies also found that slow-wave sleep enhanced glymphatic Aβ clearance from the brain when compared to wakefulness which correlates with the finding that the glymphatic stem was most busy during sleep. The restorative function of sleep may be a consequence of enhanced removal of neurotoxic wastes that accumulate in the awake.
The glymphatic system shows a dramatic decline in efficiency as we age. This might be caused by the fact that the neurotoxins that glia cells are transporting might be also toxic to the glia cells. Chronic stress and high levels of free radicals can cause chronic glial cell inflammation and over time cause its structure degeneration and declined function and decreased drainage capacity. The declined efficiency of the glymphatic system could play a role in the cognitive decline as we age. Traumatic brain injury, cerebral hemorrhage, and stroke can also affect the glymphatic system function.
Glia helps reduce the inflammation of the glymphatic system and enhances the brain’s waste drainage function. With the use addition formulas including Brown, LC Balancer and Xcel, patients can experience symptom improvement within 3 days with better focus, improved appetite, more clear thoughts and less confusion, dizziness, fatigue, headache. A significant improvement can be achieved in 2-3 weeks.
Patients who are aged or have chronic neurodegenerative conditions with a degenerated glymphatic system capacity may experience the improvement plateaus after 2-3 weeks. It is recommended to add the Gliagen to the treatment to help repair the glial cells damage and revers its degeneration and improve the transportation efficiency of the perivascular network to unload the waste to the main lymphatic system. 6 weeks to 3 months of treatment is required to have significant improvement. It is recommended to use the Glia to reduce glial cells inflammation for at least 1-2 weeks before adding the Gliagen to avoid the exacerbation of the glial cells inflammation.
If the patient’s decreased glymphatic drainage is caused by sleep deprivation, other formulas that help improve the insomnia condition are also required. For patients with chronic neurodegenerative conditions, other formulas are also required.
Suggested Dosage:
Glia: 2 capsules, 3 times a day
Gliagen: 2 capsules, 3 times a day
Ingredients:
Glia: American Ginseng, Cortex Fraxini, Cortex Phellodendri, Fructus Jujubae, Herba Lophatheri, Massa Medicata Fermentata, Nelumbo nucifera Gaertn, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Radix Astragali, Radix Ginseng, Radix Glycyrrhizae, Radix Ophiopogonis, Radix Puerariae, Rhizoma Alismatis, Rhizoma Anemarrhenae, Rhizoma Atractylodis, Rhizoma Atractylodis Macrocephalae, Rhizoma Cimicifugae, Rhizoma Coptidis, Rhizoma Zingiberis
Pinyin Name: Baishu, Cangshu, Chenpi, Danggui, Danzhuye, Dazao, Gancao, Ganjiang, Gegen, Hegeng, Huangbai, Huanglian, Huangqi, Maidong, Qinpi, Renshen, Shengma, Shenqu, Xiyanshen, Zexie, Zhimu
Gliagen: Cortex Phellodendri, Fructus Hordei Germinatus, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis, Rhizoma Atractylodis Macrocephalae, Rhizoma Gasreodiae, Rhizoma Pinelliae, Rhizoma Zingiberis
Pinyin Name: Baishu, Banxia, Cangshu, Chenpi, Dangshen, Ganjiang, Huangbai, Huangqi, Maiya, Shenqu, Tianma
References:
1. Benveniste, H., Liu, X., Koundal, S., Sanggaard, S., Lee, H., & Wardlaw, J. (2018, July 11). The Glymphatic System and Waste Clearance with Brain Aging: A Review. Retrieved from https://www.karger.com/Article/FullText/490349# 2. Newman, T. (2019, June 21). The glymphatic system: What is it and what does it do? Retrieved from https://www.karger.com/Article/FullText/490349# numerous in the brain. 3. Schiavone, S., Jaquet, V., Trabace, L., & Krause, K. H. (2013). Severe life stress and oxidative stress in the brain: from animal models to human pathology. Antioxidants & redox signaling, 18(12), 1475–1490. https://www.karger.com/Article/FullText/490349# 4. L.M. Kamendulis, J. Jiang, Y. Xu, J.E. Klaunig, Induction of oxidative stress and oxidative damage in rat glial cells by acrylonitrile , Carcinogenesis, Volume 20, Issue 8, 1 August 1999, Pages 1555–1560,
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