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Glacier clears Stomach Heat. It helps reduce digestive tract and systemic chronic inflammation to resolve insulin resistance and bring down blood sugar levels, especially fasting glucose levels. If patients experience evening blood sugar spikes after dinner, Glucacin is also recommended to reduce glucagon release from the pancreatic alfa cells.
Insulin resistance, also known as impaired insulin sensitivity, is a condition in which the body’s three primary metabolic tissues that are sensitive to insulin including skeletal muscle, fat and liver cells do not respond as it should to insulin in regulating blood glucose levels. When blood glucose can’t be taken up, the pancreatic beta cells secrete more insulin to overcome the increasing blood glucose levels. If enough insulin is released to overcome the cells’ weak response to insulin, blood sugar levels will remain in a healthy range. However, when the tissues become too resistant to insulin, blood glucose levels will be elevated. Overtime, it leads to prediabetes and type II diabetes.
Insulin is a hormone that exerts multiple effects on the whole body’s metabolism. It promotes glucose uptake by adipose tissue and skeletal muscle and prevents glucose production in the liver. Insulin also plays a key role in other important metabolic processes such as fat synthesis and storage, protein synthesis, cell growth, proliferation and differentiation. In skeletal muscle and adipose tissue insulin promotes glucose uptake by stimulating translocation of the GLUT4 glucose transporter to the cell membrane. In the liver, insulin inhibits hepatic glucose production by inhibiting the expression of key gluconeogenic enzymes and reducing gluconeogenesis activities. In adipose tissue, insulin also promotes free fatty acid uptake and reduces free fatty acid release by inhibiting lipase activity. Reduced free fatty acids levels in the blood increase insulin sensitivity in skeletal muscle.1
Although several genetic and lifestyle factors can contribute to insulin resistance, research has pointed out that inflammation plays a key role. Insulin resistance and diabetes are ultimately caused by chronic inflammation in the stomach, pancreas, liver, muscle, and fat tissues.2 Inflammation markers including C-reactive protein (CRP), interleukin-6 (IL-6), and tissue necrosis factor (TNF) can modulate insulin signaling pathways causing the tissues to become less sensitive to insulin. In muscle and adipose tissue, IL-6 decreases the number of GLUT4 glucose transporters in the cell membrane and reduces the expression of insulin receptor substrate-1 (IRS-1), the key components of insulin signal transduction pathway. In skeletal muscle, there is an inversely linear relationship between maximal glucose disposal rate and muscle TNF-α levels.3 Inflammation markers in the hepatic cell activates gluconeogenic enzymes causing enhanced gluconeogenesis in the liver.4
The chronic inflammation that contributes to insulin resistance affects not just insulin target tissues; it is at a systemic level affecting the whole body with increased levels of inflammatory markers circulating in the bloodstream. Research has identified that such systemic inflammation originates from the digestive tract. Gut dysfunction and failure of gut homeostasis causes the pathogenesis and progression of systemic inflammation due to the exacerbation of local and systemic immune responses.5 The inflammation markers generated from the gut affects the liver through the portal vein circulation and further affects the muscle, adipose and other tissues through systemic circulation.
Chronic inflammation is viewed as Heat in TCM. The gut inflammation and immune response is viewed as Stomach Heat in TCM. Glacier removes Stomach Heat and helps reduce the chronic gut inflammation as well as systemic inflammation to resolve insulin resistance in the insulin target tissues. Patients can experience reduced fasting glucose levels within 3 days. 4 weeks of treatment is required to bring blood sugar levels into the normal range.
Increased glucagon release from pancreatic alfa cells can also cause increased blood sugar levels. Patients may experience blood sugar spikes in the evening after dinner. Glucacin nurtures Kidney Yin and removes Kidney Deficiency Heat to help reduce glucagon release and the resulting high blood sugar levels especially the evening sugar spikes. Patients can experience evening blood sugar level reductions within 3 days. 4 weeks of treatment is required to bring the blood sugar levels into the normal range when used in combination with the Glacier.
Suggested Dosage: 2 capsules, 3 times a day Ingredients: Cortex Cinnamomi, Radix Et Rhizoma Rhei, Rhizoma Coptidis
Pin Yin Name: Dahuang, Huanglian, Rougui Additional Products That May be Required: Glucacin
Reference: 1. de Luca C, Olefsky JM. Inflammation and insulin resistance. FEBS Lett. 2008 Jan 9;582(1):97-105. doi: 10.1016/j.febslet.2007.11.057. Epub 2007 Nov 29. PMID: 18053812; PMCID: PMC2246086. 2. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006 Mar;17(1):4-12. PMID: 16613757. 3. Wei Y, Chen K, Whaley-Connell AT, Stump CS, Ibdah JA, Sowers JR. Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species. Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R67380. doi: 10.1152/ajpregu.00561.2007. Epub 2007 Dec 19. PMID: 18094066. 4. Kim OK, Jun W, Lee J. Mechanism of ER Stress and Inflammation for Hepatic Insulin Resistance in Obesity. Ann Nutr Metab. 2015;67(4):218-27. doi: 10.1159/000440905. Epub 2015 Oct 10. PMID: 26452040. 5. de Jong PR, González-Navajas JM, Jansen NJ. The digestive tract as the origin of systemic inflammation. Crit Care. 2016 Oct 18;20(1):279. doi: 10.1186/s13054-016-1458-3. PMID: 27751165; PMCID: PMC5067918.
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