Healthy Hormone Balance for Women of All Ages*

• Promotes healthy hormone balance, especially estrogen metabolism and detoxification, in women of all ages*
• Effectively modulates overall estrogenic activity to help provide significant relief from common symptoms of PMS (premenstrual syndrome) such as cramping, irritability and breast tenderness, as well as symptoms of perimenopause and menopause such as hot flushes, occasional mood swings and sleep imbalances*
• Helps eliminate undesirable estrogen mimics locked in hormone and neurological receptor sites*
• Promotes preferred pathways of estrogen metabolism, including the conversion of estradiol to 2-hydroxyestrone, a weaker estrogen that may help protect estrogen-sensitive tissues*

Healthy Hormone Support For Women of All Ages*
Targeted Nutritional Support for Healthy Hormone Balance. Premier Estro Complex promotes healthy hormone balance in women of all ages by featuring a broad range of targeted nutrients and synergists that support healthy estrogen metabolism and detoxification.* For women with hormone-related health concerns, supporting optimal hormone balance may provide relief and may result in improvement in common symptoms of PMS (premenstrual syndrome), perimenopause, and menopause.

Comprehensive Formula Design
What makes this formula unique is that the synergism of its broad-range nutrients address multiple concerns related to hormone balance with special emphasis on estrogen activity and metabolism. Because it exerts multiple influences, Premier Estro Complex is an excellent choice for a variety of women’s concerns. Its hormone-balancing support may provide relief for women with estrogen-excess concerns as well as providing effective nutritional support to encourage healthy estrogen balance in menopausal women.*

Estrogen Metabolism
To enable its detoxification, estrogen goes through a process called hydroxylation that yields the so-called “good” 2-hydroxyestrone (2-OH) estrogen and the less desirable 16-hydroxyestrone (16-OH) and 4-hydroxyestrone (4-OH) estrogens. Because these estrogen metabolites vary greatly in their level of estrogenic activity, their ultimate effect on the body’s tissues (whether beneficial or stressful) depends on how they are processed in the body.
The 2-OH estrogen has weak estrogenic activity, while 4-OH and 16-OH estrogens show long-acting estrogenic activity and are often associated with estrogen-excess related health concerns. Both 2-OH and 4-OH estrogens (called catechol estrogens) can be readily oxidized to quinones, which are highly reactive and can damage DNA.
However, this oxidation process can be altered if the catechol estrogens are first detoxified via Phase II liver detoxification (methylation). Therefore, the goal is to achieve an adequate nutritional status so that the liver can easily render 4-OH less reactive, while supporting the beneficial properties of 2-OH. Thus, we can see that supporting the liver detoxification pathway is a critical factor in supporting overall healthy estrogen activity.

Selective Estrogen Receptor Modulators (SERMs)
SERMs (selective estrogen receptor modulators) are non-steroidal compounds that do not contain actual estrogen hormones and are not considered to be hormones. However, these compounds are capable of binding to estrogen receptors and influencing their activities. SERMs are called “selective” because they can have estrogen-like effects on certain cells (i.e. turn on the cell’s estrogen receptor) or they can block the effects of estrogen on other cells (i.e. turn off the receptor).
In a woman with low estrogen levels, SERMs can help increase estrogen response by turning on receptors, such as during menopause – whereas in cases of high estrogen levels, SERMs help turn off estrogen receptors. SERMs support a moderate level of estrogen activity; when binding to the estrogen receptors, they can inhibit endogenous estrogen when too much is present, but at the same time, also support estrogen’s many important functions, especially for the heart, uterus, breast, vagina and bone.

Key Ingredients
DIM (Diindolylmethane)

Research shows that DIM also helps balance estrogen metabolism. Over 40 studies on DIM are on file in the National Library of Medicine database. DIM has proven to be an efficient way to help increase the ratio of estrogen metabolites in favor of the “good” estrogen. In addition to its estrogen balancing effect, DIM helps stimulate progesterone production and competes with testosterone for protein binding.
This helps to maintain testosterone in its free form (the most de-sirable form). DIM helps reduce the conversion of testosterone to estrogen.
Due to the aging process (especially prevalent when coupled with obesity or regular alcohol use), estrogen metabolism is reduced. DIM promotes healthy estrogen metabolism and helps to improve symptoms of menopause or PMS. As little as 0.5mg/kg body weight/day of DIM has been demonstrated as an effective dose. That means, for a 150 lb person, only 30 mg/day would be needed. DIM is also very effective when used in conjunction with other phytoestrogens such as isoflavones.

Chinese, Nonpesticided Royal Jelly.
Royal jelly is one of the world’s most complete, natural super nutrient concentrates (unfortunately, most sources are highly pesticided from worker bees working in pesticided fields). Royal jelly is the main source of food for the queen bee which has a life span up to 50 times longer than the worker bees. Royal jelly is rich in all of the essential B vitamins, along with natural vitamins A, C, D, E and K, more than 12 important minerals, 18 amino acids, acetylcholine (a neurotransmitter), lecithin and many other constituents.
Royal jelly is an effective anti-aging tonic with a full repertoire of master nutrients necessary to sustain life, promote longevity and vigor. Its helps to provide a feeling of well being and to promote youthfulness. Research shows that royal jelly not only promotes anti-aging and longevity, but also exerts beneficial effects on almost every body tissue as well as balancing estrogen and overall hormone metabolism. It is excellent help during pregnancy, PMS or mild menopause symptoms such as hot flashes, mood swings, night sweats and feeling “blue.” Research also supports royal jelly’s role in memory function, liver support (cholesterol), heart and circulation efficiency, skin beauty and much more.

American Ginseng

Ginseng has been used for thousands of year as a restorative. Women with hot flashes usually report the frequency and intensity of hot flashes diminished with the use of ginseng. Ginseng possesses properties that can help with sleep and also help reduce fatigue. Ginseng has been reported to produce an estrogen-like effect on the vaginal mucosa, resulting in the relief of the vaginal dryness that accompanies menopause. Ginseng has the ability to change the central neuro-endocrine system which results in ehanced mood.

Fennel

Fennel contains a variety of phytonutrients. It has been used for menstrual difficulties, ovarian disorders, and hot flashes. It is a natural remedy for menopause.

*Disclaimer: The FDA has not evaluated any of these statements. Practice at your own risk and gain. Please seek immediate medical care for any urgent trauma. This product is not intended to diagnose, treat, cure or prevent any disease