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Clearhead
Clearhead
 
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Product Code: CLEARHEAD
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Description
 
ClearHead helps clear heat and toxins from the blood, head, and gut. It helps clear toxins and bacterial infections in the central nervous system and gastrointestinal (GI) tract caused by thermotoxicities. It also helps enhance the protective mechanisms against thermotoxicities and speed up the restoration of the bodily damage.

1. Heat Stress and Heat-Related Illness
Heat stress occurs when the body can’t cool itself enough to maintain a healthy temperature. Exposure to heat can cause a reduction in blood flow and oxygen supply to the brain and other organs resulting in muscle spasms, dizziness, headache, nausea, and potentially leading to a fainting episode and loss of consciousness.

The process that helps body keep a healthy core temperature is called thermoregulation which is controlled by the hypothalamus in the brain. If temperatures and humidity are too high, the thermoregulation process may not be able to regulate the body temperature through sweating, then the core temperature will rise, and a heat-related illness will occur. The less severe form of heat-related illness is heat cramps with symptoms of painful muscle cramps and spasms. Heat exhaustion is more severe, and symptoms include moist skin with goose bumps, heavy sweating, faintness, dizziness, weak and rapid pulse, headache, nausea and rapid breathing. If left untreated, it can progress to heat stroke when the core body temperature reaches greater than 104° F. Symptoms of heat stroke include confusion or agitation, slurred speech, seizures, nausea, disorientation, and sometimes loss of consciousness or coma. Patients with heat stroke can experience long term after-effects including chronic headache, weakness, dizziness, vomiting, and muscle cramps.

High body temperatures can cause damage to the brain and other internal organs resulting in both physical and neurological problems. The central nervous system is particularly vulnerable to damage from hyperthermia and the cerebellum is particularly intolerant to the effects of heat. Hyperthermia, even if mild and only occurring for a short period, may cause cognitive impairment which can develop a short time (60–120 min) after the cessation of the hyperthermic insult.

The mechanism of thermotoxicities mainly includes disruption of blood–brain barrier (BBB) and the GI tract barrier as well as protein denature.1 The BBB is a very selective barrier of tight endothelial cells, preventing the movement of large or hydrophilic molecules, or toxic substances, from entering the brain. At temperatures above 38–39° C, the BBB will be destabilized, and the permeability of the BBB will increase, allowing proteins and ions to enter the brain. This in turn can cause inflammation, cerebral edema, and brain function interruption.

At high body temperature (above 40° C) irreversible alterations to protein structure will occur and proteins will become denatured. Denatured proteins then form aggregates which disrupt normal cellular function and prevent replication, and ultimately causing cell death in the brain. Thermal stress also induces apoptosis leading to necrotic neural death.

Systemic hyperthermia also increases the permeability of the GI tract which allows gut bacterial translocation. Hyperthermia can cause GI tract blood flow reduction, cell membrane damage, protein denature, and increased free radical production. This results in the loss of the GI barrier integrity and allows GI-derived endotoxins and bacteria to enter the body causing systemic inflammation and infections.

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. HSP are protective against a wide variety of noxious stimuli, including ischemia and hyperthermia. On exposure of the CNS to hyperthermia, HSP will be expressed predominantly in glial and Purkinje cells. Glial cells in the brain works to provide supporting functions to the nervous system. Purkinje neurons are a class of GABAergic inhibitory neurons located in the cerebellum. Many of the sensory and motor neurons of the CNS show constitutive expression of HSP 27, with further inducible expression with noxious stimuli. HSP 70 has little or no constitutive expression; its expression in Purkinje cells may be delayed by several hours, which may render the cells at risk in the immediate phases. Intracellularly located HSPs have a protective role, including correcting misfolded proteins, preventing protein aggregation, transport of proteins, and supporting antigen processing and presentation, and limiting apoptosis. However, HSP may not provide protection from all the mechanisms of thermotoxicities.

2. GI Tract and Enteric Nerve Toxicity
Bacteria toxins and toxic metabolic waste in the digestive tract can cause inflammation of the gut lining resulting in increased permeability which allows bacteria and toxins to come across the GI tract barrier. These toxic substances can cause enteric nerve toxicity. Such toxicity can also slowly move up and affect the brain. Patients can experience symptoms that are similar to heat stress symptoms including dizziness, mental fogginess, mind spaciness, forgetfulness, headache, fatigue and weakness. Research has found that the Lewy body inside the brain neurons in Parkinson patients is initially formed in the neurons of the enteric nervous system. Progress of synnucleopathy from gut to brain may take 20 years. ClearHead helps clear the toxins and bacterial infection from the central nervous system and the GI tract. ClearHead also helps to enhance the protective mechanism against thermotoxicities and speed up the restoration of the bodily damage. Herba Artemisiae Annuae, one of the herbal ingredients in ClearHead, has been traditionally used as a drug for the treatment of malaria, heat stroke, bacterial infection, and fever in Asia. It contains the ingredient artesunate which has been shown to protect the BBB and help repair BBB damage;2 Herba Artemisiae Annuae also enhances the mechanisms that support the restoration of the bodily damage caused by thermotoxicities.3 Patients can experience symptom improvement in 3-7 days. 3-4 weeks of treatment is required to have significant improvement and sustained results.

Suggested Dosage: 1 capsule, 3 times a day Available Volume: 21 capsules per bottle
Ingredients: Chrysanthemum Flower, Herba Artemisiae Annuae, Herba Eupatorii, Phaseolus Vulgaris Pinyin Name: Juhua, Qinghao, Peilan, Ludou

References
1. Walter, E. J., & Carraretto, M. (2016). The neurological and cognitive consequences of hyperthermia. Critical care (London, England), 20(1), 199. https://doi.org/10.1186/s13054-016-1376-4
2. Zhou, Z., Hou, J., & Li, Q. (2020). Artesunate attenuates traumatic brain injury-induced impairments in rats. Translational neuroscience, 11(1), 309–318. https://doi.org/10.1186/s13054-016-1376-4
3. Oh YC, Jeong YH, Kim T, Cho WK, Ma JY. Anti-inflammatory effect of Artemisiae annuae herba in lipopolysaccharide-stimulated RAW 264.7 Cells. Pharmacogn Mag. 2014 Aug;10(Suppl 3):S588-95. doi: 10.4103/0973-1296.139793. PMID: 25298679; PMCID: PMC4189277.

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