 |
 |
 |
|
Anginen-R helps nurture the mind. It helps repair the brain’s microcapillary damage, resolve the cerebral blood vessel constriction, and enhance the blood flow to the brain.
1) Reduction of Cerebral Blood Flow
The brain has an extremely high metabolic demand. It uses 20% of oxygen and glucose that the entire body consumes and is very sensitive to a reduction of blood flow. A tightly regulated blood flow and oxygen delivery is critical for survival. The body uses a specialized autoregulation system to maintain adequate and consistent brain blood flow despite changes in perfusion pressure. The autoregulation system involves a very complex coordination between the nervous and cardiovascular systems.1,2
Disruption in the autoregulation can cause reduced cerebral blood flow (CBF). Many factors can affect the autoregulation including stress, diet, sleep, exercise, and blood homocysteine levels. Endothelial cells, which line the blood vessel walls, plays a major role in autoregulation. Oxidative stress acts on the endothelium of the cerebral vessels and affects the autoregulation causing impaired CBF. Moderate elevations in homocysteine can also impair autoregulation in humans. Physical blockage and age can also be the cause. It is estimated that chronic low CBF is present in two‐thirds of individuals older than 65 years of age, 50% of people ages 50-65, and 25% of those 45-50 years old.
Reduced CBF is damaging to the brain. The mitochondria use oxygen in the final step of ATP production to take up high-energy electrons. When oxygen is low, these high-energy electrons will build up and become oxidative stress. Oxidative stress can activate inflammation and excess glutamate causing neuron damage. The inflammation can further constrict blood flow to the brain.
People may not have any symptoms until the reduction of CBF exceeds a certain level. Typical symptoms include brain fog and poor cognitive function in specific areas. A population-based study carried out from 2005-2012 found impaired CBF to be associated with increased rate of cognitive decline and a higher risk for dementia and Alzheimer’s Disease.
Depending on specific areas that may be experiencing lower CBF, various physical symptoms may be present which include muscle weakness, poor balance, dizziness, lightheadedness, trouble swallowing, impaired vision, numbness or tingling in extremities and nausea or vomiting. Decreased CBF in some brain region is also associated with many health conditions such as PTSD, depression, autism, chronic fatigue etc.
A new review article suggests that capillary damage and impaired oxygen delivery related to COVID-19 play a role in mood changes and cognitive difficulties that people with the disease face during illness and recovery. One cluster of symptoms people with COVID-19 have experienced—even after active infection has passed—is cognitive or mood impairment. This may include memory problems, depression, anxiety and brain fog, the inability to focus or concentrate. Previous research has found that people with a diagnosis of mild cognitive impairment or Alzheimer’s disease show “widespread cerebral microvascular flow disturbances.” In people with COVID-19, a shortened blood flow transit time in the capillaries limits the amount of oxygen that can be delivered to the lungs and brain. Low oxygen levels and the increase in inflammatory cytokines can also affect serotonin levels. Oxygen is crucial for the production of serotonin. Cytokines reduce serotonin levels. Low levels of serotonin can result in anxiety and lowered mood.3
The disturbed CBF and the resulting symptoms is a similar condition to fibromyalgia in which the body’s systemic microcirculation is constricted. According to Traditional Chinese Medicine (TCM), decreased CBF due to the disruption of the cerebral autoregulation and cerebral capillary constriction is viewed as a mind disturbance.
Anginen-R nurtures the mind and restores the normal blood flow to the brain. It helps repair the brain capillary damage, resolve the cerebral blood vessel constriction, and enhance the brain’s microcirculation. Ginsheng in Anginen-R boosts the body’s Qi, improves blood circulation and enhances the blood blow to the brain. Chishizhi (Halloysitum Rubrum) nurtures the blood and helps repair the brain capillary damage to restore the capillary integrity. Shichangpu (Rhizoma Acori Tatarinowii) opens the brain meridian and helps open the brain blood vessel and microcapillaries to improve the cerebral blood circulation.
Patients can experience symptom improvement in 1-2 weeks. 3-4 weeks of treatment is required to have significant improvement.
Suggested Dosage: 2 capsule3, 3 times a day
Available Volume: 42 capsules per bottle
Ingredients: Cortex Cinnamoni, Cortex Eucommiae, Halloysitum Rubrum, Poria, Radix Astragali, Radix Ginseng, Rhizoma Acori, Tatarinowii, Semen Platycladi, Thinleaf Milkwort Root
Pinyin Name: Baiziren, Chishizhi, Duzhong, Fuling, Huangqi, Renshen, Rougui, Shichangpu, Yuanzhi
1. “Low Cerebral Blood Flow: Causes, Symptoms, and Effects.” Nootopia Blog, 12 July 2022, https://nootopia.com/blog/what-is-cerebral-blood-...
2. Cipolla MJ. The Cerebral Circulation. San Rafael (CA): Morgan & Claypool Life Sciences; 2009. Chapter 5, Control of Cerebral Blood Flow. Available from: https://nootopia.com/blog/what-is-cerebral-blood-...
3. Østergaard L. SARS CoV-2 related microvascular damage and symptoms during and after COVID-19: Consequences of capillary transit-time changes, tissue hypoxia and inflammation. Physiol Rep. 2021 Feb;9(3):e14726. doi: 10.14814/phy2.14726. PMID: 33523608; PMCID: PMC7849453.
|
|
|
 |
|
 |
|
